![]() ![]() PEG lipids can further contribute to particle stability by decreasing particle aggregation, and the optimization of PEG prolong the blood circulation time of nanoparticles by reducing clearance mediated by the kidneys and the mononuclear phagocyte system. In this case, PEG is considered an 'active' ingredient, even though systemic absorption is less than 0.5. PEG 3350 is a laxative available over-the-counter by the name of Miralax. PEG 400 indicates the average molecular weight of the specific PEG at 400. ![]() The amount of PEG lipids can affect particle size. PEG diacylglycerols dont have ionic charge so those are suitable for application to drugs that are vulnerable to ionic. PEG is also available as a bowel prep for colonoscopy procedures and as a laxative. PEG lipids such as PEG2000-DMG (Figure 1) can have multiple effects on the properties of lipid nanoparticles. PEG lipid has been used extensively to improve circulation times for liposome encapsulated (LNP) drugs and reduce non-specific uptakes. PEG lipids, also known as PEGylated lipid, is a class of PEG derivatives that is attached with a lipid moiety such as DMG or DSPE. Enzyme, Antibody, Substrate NEW Select by Application ![]()
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